Atomic structure of recombinant thaumatin II reveals flexible conformations in two residues critical for sweetness and three consecutive glycine residues
نویسندگان
چکیده
منابع مشابه
Structure-sweetness relationship in thaumatin: importance of lysine residues.
To clarify the structural basis for the sweetness of thaumatin I, lysine-modified derivatives and carboxyl-group-modified derivatives were prepared by chemical modification followed by chromatographic purification. The sweetness of derivatives was evaluated by sensory analysis. Phosphopyridoxylation of lysine residues Lys78, Lys97, Lys106, Lys137 and Lys187 markedly reduced sweetness. The inten...
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In [2] it was shown that A(&, 4) = co for fe^ 1048909 and it was conjectured that A(&, 4) = =° for all k. In this paper we establish this conjecture with the following Theorem. A(&, 4) = ». Proof. It suffices to prove the theorem for values of k which are prime. The proof makes use of the following proposition which is a special case of a result of Kummer [l] (see also [3]). Proposition. Let k ...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2014
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2014.07.016